Freelite and Hevylite sensitively measure two independent biomarkers in Multiple Myeloma.
Freelite measures κ and λ free light chains (at mg/L levels) and Hevylite measures intact immunoglobulins (at g/L levels)
Using both tests when monitoring ensures detection of relapse whether by light chain and/or intact immunoglobulin clones
At relapse, a different clone may emerge to the clone seen at diagnosis (clonal evolution)
This study of an MM patient with IgAκ monoclonal proteins plus κ free light chains shows rapid identification of clonal change at both relapses
Using both Freelite and Hevylite tests during monitoring allows light chain and intact immunoglobulin clones to be detected, giving clinicians more and earlier information.