Hevylite® measures more IgA Myeloma patients during monitoring
In this study from the Mayo Clinic, USA, Dr Katzmann and colleagues compared the Hevylite heavy + light chain isotype assays to traditional laboratory methods of measuring IgA monoclonal proteins - these can be particularly difficult to quantify due to co-migration on serum protein electrophoresis (SPE). They found:
- Hevylite detected monoclonality in 3 x more IgA Multiple Myeloma monitoring samples compared to SPE
- 97% of IgA and IgG Myeloma samples had an abnormal Hevylite ratio
- Validation of all 6 Hevylite assays for routine use in the clinical laboratory showed the assay stability, linearity, accuracy and intra- and inter-assay variability were all acceptable
Monitoring IgA Multiple Myeloma: Immunoglobulin Heavy/Light Chain Assays
Katzmann J et al. Clinical Chemistry 2015; 61:360-367
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