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Home / The Science / Primary & Secondary Immunodeficiency Disorders / IgA Subclasses

IgA Subclasses

Deficiencies in IgA subclasses or alterations in the IgA1/IgA2 ratio have been related to specific diseases, recurrent infections and anaphylactic transfusion reactions

IgA is responsible for mucosal immunity and is therefore the first line of defense for the majority of infections. Normal serum concentrations of both IgA subclasses may be very low therefore a sensitive, reproducible assay is essential, particularly for pediatric samples.

Our IgA subclass assays also utilize highly specific high-affinity, polyclonal antisera and latex-enhanced reagents to enable accurate quantitation to very low levels.

Binding Site provides automated solutions for the measurement of IgA Subclasses on the Optilite®


Primary & Secondary Immunodeficiency Disorders resources

Publication

Multicenter study for the evaluation of the antibody response against salmonella typhi VI vaccination (EMPATHY) for the diagnosis of anti polysaccharide antibody production deficiency in patients with primary immunodeficiency

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Publication

Multiple myeloma and infections: a population based study on 9253 multiple myeloma patients

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Publication

Reference ranges and cutoff levels of pneumococcal antibody global serum assays (IgG and IgG2) and specific antibodies in healthy children and adults

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Publication

Kinetics of IgM and IgA antibody response to 23-valent pneumococcal polysaccharide vaccination in healthy subjects

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